Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
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چکیده
منابع مشابه
Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell's repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters containing abasic sites and 8-oxo-7, 8-dihydroguanine to investigate if the hierarchy of lesion pro...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2009
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkp1070